Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 9/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672093 | 0.80 | CYP1A2 (0.34) | HTTSMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6508090 | 0.78 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7672088 | 0.74 | CYP3A4 (0.39) | SMN1; SMN2KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7314363 | 0.72 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL10896574 | 0.71 | CYP2C9 (0.66) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7900925 | 0.69 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907983 | 0.69 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7911130 | 0.69 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6886593 | 0.69 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7138058 | 0.68 | CYP2C19 (0.38) | CYP2C19SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766669-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2005-04-20 | — | — | EP | disclosed |
| US-6245774-B1 | ANTIINFLAMMATORY AGENTS; BRONCHODILATOR AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-06-12 | — | — | US | disclosed |