Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508090 | 0.91 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7911130 | 0.90 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314363 | 0.90 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7900925 | 0.87 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6886593 | 0.86 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7914725 | 0.85 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7322059 | 0.83 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314136 | 0.83 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8770460 | 0.82 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7320173 | 0.80 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |