Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314363 | 0.94 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6508090 | 0.91 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7900925 | 0.91 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7911130 | 0.86 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907983 | 0.86 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7914725 | 0.85 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8770460 | 0.84 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7322059 | 0.83 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8688876 | 0.83 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314136 | 0.82 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1304372-C | Tri-substituted phenyl derivates useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD (GB) | 2007-03-14 | — | — | CN | disclosed |
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | disclosed |
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| CN-1151732-A | Tri-substituted phenyl derivates useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD (GB) | 1997-06-11 | — | — | CN | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |