Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653024 | 1.00 | GPR119 (0.47) | GPR119USP30LIPECHRNB2CHRNB4 | |
| SCHEMBL649953 | 1.00 | GPR119 (0.47) | GPR119USP30LIPECHRNB2CHRNB4 | |
| SCHEMBL652549 | 0.92 | CHRNB2 (0.48) | GPR119USP30CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL650346 | 0.92 | CHRNB2 (0.48) | GPR119USP30CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6782940 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3579848 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3580915 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7688783 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL653985 | 0.82 | CHRNB4 (0.48) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL653986 | 0.82 | CHRNB4 (0.48) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |