Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649954 | 1.00 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 | |
| SCHEMBL651845 | 0.82 | GPR119 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL654093 | 0.82 | GPR119 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2415457 | 0.81 | KDM4E (0.33) | — | |
| SCHEMBL652472 | 0.77 | CHRNB2 (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL651193 | 0.77 | CHRNB4 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 | |
| SCHEMBL650327 | 0.77 | CHRNB4 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 | |
| SCHEMBL3572880 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 | |
| SCHEMBL3572882 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 | |
| SCHEMBL3572884 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |