Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89401 | 0.86 | TSHR (0.71) | RENTSHRPOLBTP53THRB | |
| SCHEMBL1047741 | 0.86 | REN (0.57) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL55503 | 0.85 | REN (0.61) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL6721804 | 0.85 | REN (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL3065160 | 0.84 | REN (0.55) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL927855 | 0.84 | REN (0.55) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL1015445 | 0.83 | TSHR (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL8306331 | 0.83 | REN (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL78468 | 0.83 | REN (0.54) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL2339596 | 0.83 | TSHR (0.56) | RENTSHRKDM4EPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2005037803-A1 | ORGANIC COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2005-04-28 | — | — | WO | disclosed |