Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047741 | 0.84 | REN (0.57) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL89401 | 0.84 | TSHR (0.71) | RENTSHRCYP3A4POLBTP53 | |
| SCHEMBL6508989 | 0.83 | REN (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL55503 | 0.83 | REN (0.61) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL6721804 | 0.83 | REN (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL13618147 | 0.82 | DRD2 (0.61) | RENTSHRPOLBDRD2HTR2A | |
| SCHEMBL927855 | 0.82 | REN (0.55) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL3065160 | 0.82 | REN (0.55) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL1015445 | 0.81 | TSHR (0.56) | RENTSHRKDM4EPOLBTP53 | |
| SCHEMBL78468 | 0.81 | REN (0.54) | RENTSHRKDM4EPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |