Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509302 | 0.89 | PDPK1 (0.41) | PDPK1PSMB8MEN1KMT2APOLB | |
| SCHEMBL6512771 | 0.87 | PDPK1 (0.44) | PDPK1PSMB8MEN1KMT2APOLB | |
| SCHEMBL6513421 | 0.82 | PLK4 (0.38) | PDPK1PSMB8SYKPLK4CYP2C19 | |
| SCHEMBL6512111 | 0.79 | CTSK (0.38) | POLBCYP2C19CYP2C9KDM4ESMN1; SMN2 | |
| SCHEMBL6512117 | 0.79 | CTSK (0.38) | POLBCYP2C19CYP2C9KDM4ESMN1; SMN2 | |
| SCHEMBL6512168 | 0.79 | CTSK (0.40) | POLBCYP2C19CYP2C9SMN1; SMN2CYP2D6 | |
| SCHEMBL6512174 | 0.79 | CTSK (0.40) | POLBCYP2C19CYP2C9SMN1; SMN2CYP2D6 | |
| SCHEMBL6531499 | 0.78 | PDPK1 (0.45) | PDPK1MEN1KMT2APOLBGSK3A | |
| SCHEMBL6506223 | 0.78 | CTSK (0.42) | MEN1KMT2APOLBCYP2C19CYP2C9 | |
| SCHEMBL6510161 | 0.77 | CTSK (0.44) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |