Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | STAT1 | P42224 | 1/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | GFER | P55789 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541175 | 0.87 | MAPT (0.79) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16499476 | 0.86 | ALDH1A1 (0.65) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL417825 | 0.86 | ALDH1A1 (0.71) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9862039 | 0.85 | ALDH1A1 (0.69) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14837509 | 0.85 | MAPT (0.60) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14395420 | 0.83 | ALDH1A1 (0.52) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22906080 | 0.83 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6263502 | 0.83 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL419961 | 0.83 | MEN1 (0.77) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15245183 | 0.81 | KDM4E (0.62) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |