Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508526 | 0.86 | PTK2 (0.40) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL11636830 | 0.79 | ALDH1A1 (0.34) | ALDH1A1KDM5A | |
| SCHEMBL7002263 | 0.75 | MAPK8 (0.49) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL546304 | 0.71 | PTK2 (0.59) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL6506529 | 0.71 | KDM5A (0.36) | KMT2AMEN1KDM5A | |
| SCHEMBL6512268 | 0.71 | IKBKB (0.35) | KMT2AMEN1MAPK1KDM5A | |
| SCHEMBL7616569 | 0.71 | PTK2 (0.44) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL1680689 | 0.71 | PTK2 (0.73) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL3337813 | 0.71 | PTK2 (0.49) | PTK2MAPK8MAPK10ALDH1A1MAPT | |
| SCHEMBL10653177 | 0.70 | SMN1; SMN2 (0.56) | ALDH1A1MAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |