Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 10/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506529 | 0.83 | KDM5A (0.36) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6514944 | 0.81 | KDM5A (0.37) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6505649 | 0.80 | IKBKB (0.45) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6506816 | 0.77 | CHEK1 (0.36) | IKBKBCHEK1MAPK1 | |
| SCHEMBL6505745 | 0.72 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6509499 | 0.71 | PTK2 (0.40) | MEN1KMT2AKDM5AMAPK1 | |
| Hydrochloric Acid SCHEMBL6510283 | 0.70 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6512326 | 0.70 | IKBKB (0.36) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6508772 | 0.69 | IKBKB (0.38) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6508526 | 0.64 | PTK2 (0.40) | MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |