SCHEMBL6509539

SCHEMBL6509539

CC(CO)(CCCCN(CCCCC(C)(CO)c1ccccc1)C(=O)NS)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.40
HIF1A Q16665 1/20 0.40
SIGMAR1 Q99720 1/20 0.37
OPRM1 P35372 2/20 0.34
DRD3 P35462 2/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
HDAC1 Q13547 4/20 0.33
HDAC3 O15379 3/20 0.33
HDAC2 Q92769 3/20 0.33
HDAC6 Q9UBN7 3/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
HDAC8 Q9BY41 3/20 0.33
HDAC4 P56524 2/20 0.33
HDAC7 Q8WUI4 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
HDAC10 Q969S8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6448291 0.81 CYP2C19 (0.41) CYP2C19HIF1ASIGMAR1OPRM1DRD3
SCHEMBL6392028 0.79 CYP2C19 (0.40) CYP2C19HIF1ASIGMAR1OPRM1DRD3
SCHEMBL3280032 0.77 CYP2C19 (0.49) CYP2C19HIF1ASIGMAR1OPRM1DRD3
SCHEMBL6389157 0.77 CYP2C19 (0.38) CYP2C19HIF1ASIGMAR1OPRM1DRD3
SCHEMBL3279785 0.76 CYP2C19 (0.47) CYP2C19HIF1AHDAC1HDAC3HDAC2
SCHEMBL3279295 0.75 CYP2C19 (0.50) CYP2C19HIF1AOPRM1DRD3DRD2
SCHEMBL3284019 0.72 CYP2C19 (0.44) CYP2C19HIF1ASIGMAR1OPRM1DRD3
SCHEMBL6392645 0.72 CYP2C19 (0.47) CYP2C19HIF1AHDAC1HDAC3HDAC2
SCHEMBL6387814 0.72 CYP2C19 (0.47) CYP2C19HIF1AHDAC1HDAC3HDAC2
SCHEMBL6512880 0.72 LMNA (0.39) CYP2C19HIF1ASIGMAR1OPRM1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005068420-A1 UREA AND THIOUREA COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2005-07-28 WO claimed
WO-2005068420-A1 UREA AND THIOUREA COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2005-07-28 WO disclosed