Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6389157 | 0.95 | CYP2C19 (0.38) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL6509539 | 0.81 | CYP2C19 (0.40) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL6512880 | 0.80 | LMNA (0.39) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL3279785 | 0.78 | CYP2C19 (0.47) | CYP2C19HIF1AMAPTKMT2ALMNA | |
| SCHEMBL6395471 | 0.77 | KIF11 (0.47) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL6396071 | 0.77 | FDPS (0.43) | SIGMAR1LMNAALDH1A1LTB4R | |
| SCHEMBL6396052 | 0.77 | AOC3 (0.43) | KMT2ASIGMAR1LMNAALDH1A1LTB4R | |
| SCHEMBL3280032 | 0.76 | CYP2C19 (0.49) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL6387815 | 0.76 | KIF11 (0.48) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 | |
| SCHEMBL6515224 | 0.75 | SIGMAR1 (0.38) | CYP2C19HIF1AMAPTKMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192347-A1 | Urea and thiourea compounds and compositions for cholesterol management and related uses | ESPERION THERAPEUTICS, INC. | 2005-09-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192347-A1 | Urea and thiourea compounds and compositions for cholesterol management and related uses | PNLIP, FABP2, GPR119 | CYP2C19 1162/4885HIF1A 3981/4885MAPT 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.