Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535545 | 0.92 | HPGD (0.48) | IRAK4HPGDCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL11169214 | 0.85 | KDM4E (0.50) | HPGDCYP2D6ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL1034425 | 0.82 | CYP1A2 (0.46) | HPGDCYP2D6ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL1032977 | 0.77 | BRD4 (0.44) | HPGDCYP2D6ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL1032978 | 0.77 | BRD4 (0.44) | HPGDCYP2D6ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL6511034 | 0.77 | IRAK4 (0.48) | IRAK4MAPK8CHEK1CDK1MELK | |
| SCHEMBL4705404 | 0.76 | UTS2R (0.40) | CYP2D6CYP3A4CYP1A2CYP2C19USP2 | |
| SCHEMBL31403002 | 0.75 | JAK3 (0.49) | IRAK4CYP2D6CYP3A4HSD11B1HSD11B2 | |
| SCHEMBL13003296 | 0.74 | ACHE (0.71) | LMNASMN1; SMN2RAB9APOLBKDM4E | |
| SCHEMBL3811583 | 0.73 | KIT (0.46) | CYP2D6CYP3A4CYP1A2CYP2C19USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250100994-A1 | CDK12/13 COVALENT INHIBITORS OR PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | UNIV MICHIGAN REGENTS (US) | 2025-03-27 | — | — | US | disclosed |
| CN-117658982-A | Novel CDK12/13 covalent inhibitor or pharmaceutical composition and application thereof | 中国科学院上海有机化学研究所 | 2024-03-08 | — | — | CN | disclosed |
| WO-2005095339-A1 | DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250100994-A1 | CDK12/13 COVALENT INHIBITORS OR PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | CDK12, CDK1, CDK13 | IRAK4 3218/4885HPGD 2556/4885CYP2D6 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.