Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509693 | 0.77 | IRAK4 (0.48) | IRAK4CHEK1MAPK8MELKCDK1 | |
| SCHEMBL28866276 | 0.69 | CHUK (0.38) | IRAK4CTSKCHUK | |
| SCHEMBL29164583 | 0.69 | IRAK4 (0.55) | IRAK4CDK2CTSKCDK1 | |
| SCHEMBL15221628 | 0.67 | LRRK2 (0.40) | IRAK4UTS2RLRRK2 | |
| SCHEMBL4535545 | 0.67 | HPGD (0.48) | IRAK4UTS2RLRRK2 | |
| SCHEMBL15233041 | 0.66 | KDM4E (0.64) | IRAK4CHEK1MAPK8CDK2MELK | |
| SCHEMBL473432 | 0.66 | KDM4E (0.64) | IRAK4CHEK1MAPK8CDK2MELK | |
| SCHEMBL6508486 | 0.66 | KDM4E (0.64) | IRAK4CHEK1MAPK8CDK2MELK | |
| SCHEMBL21333401 | 0.66 | — | — | |
| SCHEMBL3808208 | 0.66 | CCNK (0.56) | IRAK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095339-A1 | DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |