Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 7/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533319 | 0.77 | HCAR3 (0.41) | PTPN1 | |
| SCHEMBL6508607 | 0.76 | KDM4E (0.47) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL28905229 | 0.75 | TYMS (0.53) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL2638767 | 0.75 | TYMS (0.53) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL27564186 | 0.72 | CA2 (0.75) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL8722915 | 0.72 | FOLH1 (0.48) | FOLH1CCKBR | |
| SCHEMBL9827556 | 0.71 | GAA (0.51) | CA2CA1KDM4EHPGDTYMS | |
| SCHEMBL6509910 | 0.71 | KDM4E (0.40) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL19418983 | 0.71 | CA2 (0.54) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL2638361 | 0.70 | TYMS (0.51) | CA2CA1CA12CA9TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165493-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000058271-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-05 | — | — | WO | claimed |
| US-6852755-B1 | Nitrogen mustard compounds and prodrugs therefor | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2005-02-08 | — | — | US | disclosed |
| EP-1165493-B1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER REC TECH LTD (GB) | 2005-01-19 | — | — | EP | disclosed |
| US-20040014187-A1 | Bacterial carboxypeptidase cpg2 variants and their use in gene directed enzyme prodrug therapy | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2004-01-22 | — | — | US | disclosed |
| EP-1280921-A1 | BACTERIAL CARBOXYPEPTIDASE CPG2 VARIANTS AND THEIR USE IN GENE DIRECTED ENZYME PRODRUG THERAPY | Cancer Research Ventures Limited (GB) | 2003-02-05 | — | — | EP | disclosed |
| EP-1165493-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2001085960-A1 | BACTERIAL CARBOXYPEPTIDASE CPG2 VARIANTS AND THEIR USE IN GENE DIRECTED ENZYME PRODRUG THERAPY | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-11-15 | — | — | WO | disclosed |
| WO-2000058271-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-05 | — | — | WO | disclosed |