Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 6/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410649 | 0.92 | AR (0.44) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL3055456 | 0.84 | TRPV4 (0.38) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL3527583 | 0.81 | TRPV4 (0.45) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL11799852 | 0.78 | GAA (0.38) | ABCB1 | |
| SCHEMBL2584317 | 0.77 | MRGPRX4 (0.44) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL3525556 | 0.76 | TRPV4 (0.43) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL250976 | 0.76 | TRPV4 (0.49) | TRPV4KIF11MRGPRX4ARCYP19A1 | |
| SCHEMBL11804570 | 0.74 | GAA (0.38) | ABCB1 | |
| SCHEMBL6511318 | 0.73 | SRD5A2 (0.42) | MRGPRX4ARP4HB | |
| SCHEMBL3051276 | 0.72 | TRPV4 (0.40) | TRPV4KIF11MRGPRX4ARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852755-B1 | Nitrogen mustard compounds and prodrugs therefor | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2005-02-08 | — | — | US | disclosed |
| EP-1165493-B1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER REC TECH LTD (GB) | 2005-01-19 | — | — | EP | disclosed |
| EP-1165493-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058271-A1 | NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-05 | — | — | WO | disclosed |