SCHEMBL6511318

SCHEMBL6511318

O=C(O)c1ccc(N(CCO)CCO)c(C(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 2/20 0.42
HCAR3 P49019 2/20 0.42
ALDH1A1 P00352 1/20 0.40
ADH5 P11766 1/20 0.39
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
P4HB P07237 1/20 0.38
RXRA P19793 3/20 0.37
RXRB P28702 3/20 0.37
RXRG P48443 3/20 0.37
MRGPRX4 Q96LA9 1/20 0.37
RARA P10276 4/20 0.37
RARB P10826 4/20 0.37
RARG P13631 4/20 0.37
AR P10275 1/20 0.37
TTR P02766 1/20 0.36
EPHX2 P34913 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6533319 0.87 HCAR3 (0.41) SRD5A2HCAR3ALDH1A1ADH5AKR1C3
SCHEMBL3529075 0.83 HCAR3 (0.55) SRD5A2HCAR3ADH5AKR1C3AKR1C2
SCHEMBL3529077 0.78 HCAR3 (0.46) SRD5A2HCAR3ADH5AKR1C3AKR1C2
SCHEMBL16121258 0.74 ACE2 (0.53) SRD5A2ALDH1A1ADH5AKR1C3AKR1C2
SCHEMBL7470554 0.74 ALDH1A1 (0.53) ALDH1A1AKR1C3AKR1C2AR
SCHEMBL6509894 0.73 TRPV4 (0.43) P4HBMRGPRX4AR
SCHEMBL31319449 0.73 RXRA (0.48) SRD5A2ADH5P4HBRXRARXRB
SCHEMBL827082 0.73 RXRA (0.48) SRD5A2ADH5P4HBRXRARXRB
SCHEMBL18373540 0.72 HCAR3 (0.57) HCAR3ALDH1A1RXRARXRBRXRG
SCHEMBL336261 0.71 ADH5 (0.54) SRD5A2ADH5AKR1C3AKR1C2P4HB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6852755-B1 Nitrogen mustard compounds and prodrugs therefor CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2005-02-08 US disclosed
EP-1165493-B1 NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR CANCER REC TECH LTD (GB) 2005-01-19 EP disclosed
EP-1165493-A1 NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2002-01-02 EP disclosed
WO-2000058271-A1 NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-10-05 WO disclosed