SCHEMBL6509927

SCHEMBL6509927

C#Cc1cc([N+](=O)[O-])c(C#C)cc1N

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN11 Q06124 2/20 0.53
TDP1 Q9NUW8 5/20 0.41
ALDH1A1 P00352 5/20 0.41
CYP3A4 P08684 4/20 0.41
MAPT P10636 4/20 0.41
TSHR P16473 3/20 0.41
POLB P06746 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALOX15 P16050 1/20 0.41
PTPN1 P18031 1/20 0.39
PTPN6 P29350 1/20 0.39
GPR35 Q9HC97 1/20 0.38
MCL1 Q07820 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
APEX1 P27695 1/20 0.37
BLM P54132 1/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2983584 0.84 TSHR (0.47) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL6516638 0.77 PTPN11 (0.43) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL6516643 0.76 TDP1 (0.42) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL29029244 0.76 PTPN1 (0.56) PTPN11PTPN1PTPN6
SCHEMBL17875621 0.76 ALDH1A1 (0.58) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL28628385 0.73 TDP1 (0.55) TDP1ALDH1A1CYP3A4MAPTTSHR
SCHEMBL19606264 0.71 MAPT (0.50) TDP1ALDH1A1CYP3A4MAPTTSHR
SCHEMBL1754838 0.70 TDP1 (0.51) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL11898342 0.70 ALDH1A1 (0.53) PTPN11TDP1ALDH1A1CYP3A4MAPT
SCHEMBL9793498 0.69 PTPN11 (0.49) PTPN11TDP1ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed