SCHEMBL6509956

SCHEMBL6509956

C#Cc1ccc(-c2ccc(C#C)c(N)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
PTPN1 P18031 1/20 0.36
PTPN6 P29350 1/20 0.36
PTPN11 Q06124 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
ALDH1A1 P00352 3/20 0.34
ALOX15 P16050 2/20 0.34
HSD17B10 Q99714 2/20 0.34
KDM4E B2RXH2 1/20 0.34
USP2 O75604 1/20 0.34
LMNA P02545 1/20 0.34
HSP90AA1 P07900 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL689115 0.83 PTPN1 (0.41) PTPN1PTPN6PTPN11CA12CA1
SCHEMBL139848 0.75 HDAC8 (0.50) PTPN1CA12CA1CA2CA4
SCHEMBL139611 0.75 HDAC8 (0.50) PTPN1CA12CA1CA2CA4
SCHEMBL9659495 0.73 CYP3A4 (0.58) MEN1KMT2ATDP1CA12CA1
SCHEMBL6509952 0.73 AR (0.36) MEN1KMT2ATDP1PTPN1PTPN6
SCHEMBL4101868 0.73 HDAC8 (0.43) PTPN1CA12CA1CA2CA4
Water SCHEMBL11190539 0.72 HDAC8 (0.48) PTPN1CA12CA1CA2CA4
SCHEMBL10481156 0.72 HDAC8 (0.48) PTPN1CA12CA1CA2CA4
SCHEMBL7608526 0.72 NPC1 (0.38) MEN1KMT2ALMNAMAPTHTT
SCHEMBL3838919 0.72 MEN1 (0.48) MEN1KMT2ACA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed