Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.73 |
| ▸ | HTR2B | P41595 | 3/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30604550 | 0.88 | HTR2C (0.81) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6507511 | 0.88 | HTR2C (0.77) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL30001608 | 0.87 | HTR2C (0.80) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6510388 | 0.85 | HTR2C (0.72) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL20111165 | 0.84 | HTR2C (1.00) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6510239 | 0.83 | HTR2C (0.77) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6508031 | 0.83 | HTR2C (0.77) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6511003 | 0.83 | HTR2C (0.73) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL30001565 | 0.83 | HTR2C (0.80) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6511990 | 0.83 | HTR2C (0.80) | HTR2CHTR2BHDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |