Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662525 | 0.77 | HAO1 (0.46) | MAPTMEN1KMT2AHAO1SMN1; SMN2 | |
| SCHEMBL4743804 | 0.77 | HPGD (0.53) | MAPTHAO1SMN1; SMN2IDO1PTGIR | |
| SCHEMBL1621722 | 0.75 | HAO1 (0.47) | MAPTMEN1KMT2AHAO1SMN1; SMN2 | |
| SCHEMBL482369 | 0.74 | CA1 (0.65) | MAPTMEN1KMT2AHAO1GAA | |
| SCHEMBL30390610 | 0.73 | MAPT (0.50) | MAPTMEN1KMT2AHAO1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11848856 | 0.72 | CA1 (0.61) | MAPTMEN1KMT2AHAO1GAA | |
| SCHEMBL3451541 | 0.71 | KDM4E (0.67) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7763044 | 0.70 | CYP2A6 (0.60) | MEN1KMT2APOLBPTGIRKDM4E | |
| SCHEMBL829981 | 0.70 | AURKA (0.48) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6514826 | 0.69 | ALDH1A1 (0.49) | MAPTSMN1; SMN2LMNAHSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |