Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.64 |
| ▸ | HTR2B | P41595 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511220 | 1.00 | HTR2C (0.64) | HTR2CHTR2BNPC1CYP1A2CYP2D6 | |
| SCHEMBL6507511 | 0.92 | HTR2C (0.77) | HTR2CHTR2BNPC1RAB9AKDM4E | |
| SCHEMBL7309411 | 0.89 | HTR2C (0.67) | HTR2CHTR2BKDM4EHDAC1GID4 | |
| SCHEMBL6510388 | 0.89 | HTR2C (0.72) | HTR2CHTR2BNPC1RAB9AHDAC3 | |
| SCHEMBL6509995 | 0.88 | HTR2C (0.60) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6518480 | 0.88 | HTR2C (0.68) | HTR2CHTR2BKDM4EHDAC3HDAC1 | |
| SCHEMBL15833076 | 0.85 | HTR2C (0.61) | HTR2CHTR2BKDM4EHDAC3HDAC1 | |
| SCHEMBL21377089 | 0.84 | HTR2C (0.62) | HTR2CHTR2BKDM4EHDAC3HDAC1 | |
| SCHEMBL6509968 | 0.84 | HTR2C (0.57) | HTR2CHTR2BKDM4EHDAC3HDAC1 | |
| SCHEMBL15833088 | 0.84 | HTR2C (0.62) | HTR2CHTR2BKDM4EHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |