Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.57 |
| ▸ | HTR2B | P41595 | 3/20 | 0.57 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510397 | 0.88 | HTR2C (0.58) | HTR2CHTR2BGID4KDM4EHDAC3 | |
| SCHEMBL6509995 | 0.85 | HTR2C (0.60) | HTR2CHTR2BGID4HDAC3HDAC1 | |
| SCHEMBL6511220 | 0.84 | HTR2C (0.64) | HTR2CHTR2BGID4KDM4EHDAC3 | |
| SCHEMBL6510792 | 0.84 | HTR2C (0.64) | HTR2CHTR2BGID4KDM4EHDAC3 | |
| SCHEMBL6507511 | 0.84 | HTR2C (0.77) | HTR2CHTR2BGID4KDM4EHDAC3 | |
| SCHEMBL7309411 | 0.83 | HTR2C (0.67) | HTR2CHTR2BGID4KDM4EHDAC1 | |
| SCHEMBL6510388 | 0.81 | HTR2C (0.72) | HTR2CHTR2BGID4HDAC3HDAC1 | |
| SCHEMBL21540800 | 0.78 | TAAR1 (0.63) | HTR2CHTR2BKDM4E | |
| SCHEMBL18019717 | 0.76 | PKM (0.57) | HTR2CHTR2BGID4 | |
| SCHEMBL3856002 | 0.76 | GID4 (0.54) | HTR2CHTR2BGID4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |