Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511622 | 0.88 | S1PR1 (0.57) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6510804 | 0.88 | S1PR1 (0.57) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6511220 | 0.88 | HTR2C (0.64) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6510792 | 0.88 | HTR2C (0.64) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6507511 | 0.88 | HTR2C (0.77) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6510388 | 0.85 | HTR2C (0.72) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6509968 | 0.85 | HTR2C (0.57) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL7309411 | 0.81 | HTR2C (0.67) | HTR2CHTR2BHDAC1GID4P2RX7 | |
| SCHEMBL6510385 | 0.78 | HTR2C (0.73) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL30604550 | 0.77 | HTR2C (0.81) | HTR2CHTR2BHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |