Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 15/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505096 | 0.87 | IKBKB (0.47) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6512362 | 0.83 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6506340 | 0.82 | FLT3 (0.51) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6514964 | 0.81 | CHEK1 (0.57) | IKBKBMEN1KMT2ATDP1CHEK1 | |
| SCHEMBL6530168 | 0.81 | IKBKB (0.62) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6998767 | 0.81 | KDM4E (0.59) | IKBKBGRM5MEN1KMT2AMAPK8 | |
| SCHEMBL6510003 | 0.80 | P2RX1 (0.52) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6507704 | 0.80 | CHEK1 (0.49) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6510633 | 0.79 | MEN1 (0.48) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL7055075 | 0.77 | IKBKB (0.71) | IKBKBJAK2JAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |