Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413693 | 0.83 | BAZ2B (0.46) | KDM4EALOX15HTTFGFR1CNR2 | |
| SCHEMBL6513795 | 0.83 | MCL1 (0.56) | KDM4EFGFR1CNR2ALDH1A1HPGD | |
| SCHEMBL13682851 | 0.79 | MAPK1 (0.46) | KDM4EHTTCNR2ALDH1A1HPGD | |
| SCHEMBL10110861 | 0.79 | MAPT (0.38) | KDM4EALOX15HTTCNR2ALDH1A1 | |
| SCHEMBL1423541 | 0.76 | L3MBTL1 (0.49) | KDM4EL3MBTL1ALOX15HTTCNR2 | |
| SCHEMBL20552536 | 0.75 | L3MBTL1 (0.55) | KDM4EL3MBTL1ALDH1A1HPGDMAPT | |
| SCHEMBL4486403 | 0.74 | L3MBTL1 (0.67) | KDM4EL3MBTL1ALDH1A1HPGDMAPT | |
| SCHEMBL29834903 | 0.74 | L3MBTL1 (0.67) | KDM4EL3MBTL1ALDH1A1HPGDMAPT | |
| Bromide SCHEMBL31705791 | 0.73 | GRM4 (0.43) | KDM4ECNR2ALDH1A1HPGDMAPT | |
| SCHEMBL2276664 | 0.73 | L3MBTL1 (0.52) | KDM4EL3MBTL1ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-10-01 | — | — | US | disclosed |
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| WO-2004099131-A2 | COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA | PHARMACIA CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PCNA, POLM, PBRM1 | KDM4E 3756/4885L3MBTL1 750/4885ALOX15 4717/4885 |
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMB5, PSMC2 | KDM4E 225/4885L3MBTL1 1841/4885ALOX15 3049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.