Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152522 | 1.00 | MEN1 (0.52) | MEN1KMT2AHPGDRXFP1USP2 | |
| SCHEMBL17152403 | 1.00 | MEN1 (0.52) | MEN1KMT2AHPGDRXFP1USP2 | |
| SCHEMBL17152615 | 0.96 | MEN1 (0.51) | MEN1KMT2AHPGDRXFP1USP2 | |
| SCHEMBL12312072 | 0.82 | MEN1 (0.54) | MEN1KMT2AHPGDRXFP1USP2 | |
| SCHEMBL12573346 | 0.82 | MEN1 (0.54) | MEN1KMT2AHPGDRXFP1USP2 | |
| SCHEMBL17152425 | 0.82 | ALDH1A1 (0.39) | MEN1KMT2ARXFP1KDM4EALDH1A1 | |
| SCHEMBL12880452 | 0.82 | MEN1 (0.59) | MEN1KMT2AHPGDUSP2SMN1; SMN2 | |
| SCHEMBL14368076 | 0.82 | MEN1 (0.59) | MEN1KMT2AHPGDUSP2SMN1; SMN2 | |
| SCHEMBL8404634 | 0.82 | MEN1 (0.59) | MEN1KMT2AHPGDUSP2SMN1; SMN2 | |
| SCHEMBL18421342 | 0.81 | MEN1 (0.40) | MEN1KMT2AHPGDRXFP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |