Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.72 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.72 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.72 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.72 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.72 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.72 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.72 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6720704 | 0.87 | SIGMAR1 (0.86) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL27003088 | 0.86 | SIGMAR1 (0.85) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6422901 | 0.85 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6717633 | 0.84 | SIGMAR1 (0.86) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6513644 | 0.80 | SIGMAR1 (0.64) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6507964 | 0.80 | SIGMAR1 (0.72) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6720803 | 0.79 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6509097 | 0.78 | MAPK1 (0.54) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5922956 | 0.78 | MAPT (0.53) | CYP1A2POLBLMNAKMT2AMAPK1 | |
| SCHEMBL6509984 | 0.78 | MAPK1 (0.54) | SIGMAR1CYP2D6CYP1A2POLBCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |