Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 6/20 | 0.37 |
| ▸ | CTSL | P07711 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510135 | 0.87 | CTSK (0.44) | CTSKCTSSCTSL | |
| SCHEMBL6510161 | 0.87 | CTSK (0.44) | CTSKCTSSCTSLLMNATP53 | |
| SCHEMBL6513831 | 0.86 | CTSK (0.44) | CTSKCTSSCTSL | |
| SCHEMBL6506223 | 0.86 | CTSK (0.42) | CTSKGAACTSSCTSLKMT2A | |
| SCHEMBL6527852 | 0.85 | CTSK (0.40) | CTSKMAPTCTSSCTSLSMN1; SMN2 | |
| SCHEMBL6512117 | 0.84 | CTSK (0.38) | CTSKMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL6512168 | 0.84 | CTSK (0.40) | CTSKMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL6512174 | 0.84 | CTSK (0.40) | CTSKMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL6512111 | 0.84 | CTSK (0.38) | CTSKMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL6509302 | 0.83 | PDPK1 (0.41) | CTSKGAAKMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |