Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MDH1 | P40925 | 2/20 | 0.41 |
| ▸ | MDH2 | P40926 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543157 | 0.89 | HTT (0.48) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL13936405 | 0.81 | CA1 (0.49) | KDM4EALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL30159616 | 0.80 | KDM4A (0.41) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL23535771 | 0.80 | KDM4A (0.41) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1206765 | 0.79 | HDAC3 (0.53) | HTTKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL4490699 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL1206741 | 0.79 | BRD4 (0.45) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16318447 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10HPGDL3MBTL1 | |
| SCHEMBL17238956 | 0.75 | PDK1 (0.55) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL21056153 | 0.75 | KDM4E (0.50) | HTTKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| WO-2004099131-A2 | COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA | PHARMACIA CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PCNA, POLM, PBRM1 | HTT 161/4885KDM4E 3756/4885ALDH1A1 4554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.