Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MDH1 | P40925 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31104508 | 0.87 | MAPT (0.50) | KDM4ESMN1; SMN2ALDH1A1HTTPYGL | |
| SCHEMBL11959263 | 0.87 | MAPT (0.50) | KDM4ESMN1; SMN2ALDH1A1HTTPYGL | |
| SCHEMBL17414151 | 0.86 | LPAR1 (0.50) | SMN1; SMN2ALDH1A1HTTMAPTHSD17B10 | |
| SCHEMBL17238964 | 0.85 | MAPT (0.45) | KDM4ESMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL17238956 | 0.85 | PDK1 (0.55) | KDM4ESMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL16709750 | 0.83 | MEN1 (0.45) | KDM4ESMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL24890788 | 0.82 | PYGL (0.39) | KDM4EALDH1A1HTTPYGLMGLL | |
| SCHEMBL658391 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HTTMAPTSUV39H2GAA | |
| SCHEMBL31016366 | 0.80 | MAPT (0.41) | KDM4ESMN1; SMN2ALDH1A1PYGLMGLL | |
| SCHEMBL661882 | 0.79 | MEN1 (0.62) | KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498712-B1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO LTD (CN) | 2024-01-03 | — | — | EP | disclosed |
| CN-113387957-B | Spirocyclic indolone-pyrrolidine carbonate compound and composition, preparation method and application thereof | 江苏亚尧生物科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-113387957-A | Spirocyclic indolone-pyrrolidine carbonate compound and composition, preparation method and application thereof | 江苏亚尧生物科技有限公司 | 2021-09-14 | — | — | CN | disclosed |
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | Xiao, Fei (CN) | 2019-11-12 | — | — | US | disclosed |
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | Xiao, Fei (CN) | 2019-11-12 | — | — | US | disclosed |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | JIANGSU YAYO BIOTECHNOLOGY CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| CN-107698598-B | Spiro indole ketone polyethylene glycol carbonates class compound and its composition, Preparation method and use | 肖飞 | 2019-06-21 | — | — | CN | disclosed |
| EP-3498712-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | Xiao, Fei (CN) | 2019-06-19 | — | — | EP | disclosed |
| CN-107698598-A | Spiro indole ketone polyethylene glycol carbonates class compound and its composition, Preparation method and use | 肖飞 | 2018-02-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10471154-B2 | Spirocyclic indolone polyethylene glycol carbonate compound, composition, preparation method and use thereof | SI, MKI67, HSD17B7 | KDM4E 3386/4885SMN1; SMN2 4692/4885ALDH1A1 1952/4885 |
| US-20190209700-A1 | SPIROCYCLIC INDOLONE POLYETHYLENE GLYCOL CARBONATE COMPOUND, COMPOSITION, PREPARATION METHOD AND USE THEREOF | SI, HSD17B7, MKI67 | KDM4E 3405/4885SMN1; SMN2 4672/4885ALDH1A1 2018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.