SCHEMBL6513277

SCHEMBL6513277

CCn1nc(C)cc1C(=O)NC(CC(=O)O)c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 16/20 0.46
ITGA4 P13612 16/20 0.46
MAPT P10636 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
SMYD3 Q9H7B4 1/20 0.43
FLT1 P17948 1/20 0.43
KDR P35968 1/20 0.43
CYP26A1 O43174 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6509549 0.83 ITGB1 (0.63) ITGB1ITGA4
SCHEMBL6513196 0.81 ITGB1 (0.53) ITGB1ITGA4
SCHEMBL6513307 0.76 ITGB1 (0.48) ITGB1ITGA4CYP26A1
SCHEMBL6520295 0.76 ITGB1 (0.48) ITGB1ITGA4
SCHEMBL6512395 0.76 ITGB1 (0.49) ITGB1ITGA4
SCHEMBL6509525 0.76 ITGB1 (0.52) ITGB1ITGA4MAPTKDRCYP26A1
SCHEMBL6520277 0.76 ITGB1 (0.51) ITGB1ITGA4MAPTKDRCYP26A1
SCHEMBL6518236 0.76 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL6512380 0.75 ITGA4 (0.50) ITGB1ITGA4
SCHEMBL6518082 0.74 ITGB1 (0.57) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6953798-B1 β-alanine derivates CELLTECH R&D LIMITED (GB) 2005-10-11 US disclosed