Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512878 | 0.90 | TRPA1 (0.42) | CNR1CNR2AKR1B10AVPR2AVPR1A | |
| SCHEMBL6509849 | 0.83 | CNR1 (0.51) | CNR1AVPR2AVPR1A | |
| SCHEMBL6514331 | 0.82 | CNR1 (0.42) | CNR1CNR2AVPR2AVPR1ASMN1; SMN2 | |
| SCHEMBL6508430 | 0.82 | CNR1 (0.44) | CNR1CNR2AVPR2AVPR1A | |
| SCHEMBL8261401 | 0.74 | CNR1 (0.45) | CNR1CNR2KDM4EMAPTPOLB | |
| SCHEMBL4832926 | 0.74 | CNR1 (0.45) | CNR1CNR2KDM4EMAPTPOLB | |
| SCHEMBL5391337 | 0.73 | MAPT (0.49) | CNR1CNR2KDM4ETDP1MAPT | |
| SCHEMBL14577345 | 0.73 | MEN1 (0.62) | CNR1CNR2KDM4ETDP1MAPT | |
| SCHEMBL5375242 | 0.73 | MAPT (0.64) | CNR1CNR2KDM4ETDP1MAPT | |
| SCHEMBL6506902 | 0.73 | CNR1 (0.44) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |