⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10750620 | 0.78 | MEN1 (0.32) | — | |
| SCHEMBL2269826 | 0.71 | — | — | |
| SCHEMBL27898526 | 0.71 | — | — | |
| SCHEMBL8805899 | 0.71 | — | — | |
| SCHEMBL7788031 | 0.71 | — | — | |
| SCHEMBL28195033 | 0.71 | — | — | |
| SCHEMBL17562261 | 0.70 | RXRA (0.38) | — | |
| SCHEMBL6826431 | 0.70 | MEN1 (0.41) | — | |
| SCHEMBL29041902 | 0.70 | RXRA (0.33) | — | |
| SCHEMBL7794820 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050266422-A1 | Fluoroalkoxy, nucleosides, nucleotides, and polynucleotides | SIRNA THERAPEUTICS, INC. (US) | 2005-12-01 | — | — | US | claimed |
| CN-110452173-A | A kind of new method for manufacturing pyrazoles or pyrimidone | FUJIAN YONGJING TECH CO LTD | 2019-11-15 | — | — | CN | disclosed |
| CN-107074845-A | The manufacture method of pyrazole derivatives | 持田制药株式会社 | 2017-08-18 | — | — | CN | disclosed |
| CN-107074844-A | The manufacture method of pyrazole derivatives | 持田制药株式会社 | 2017-08-18 | — | — | CN | disclosed |
| CN-107011343-A | Novel pyrazole derivative | 持田制药株式会社 | 2017-08-04 | — | — | CN | disclosed |
| CN-106957317-A | Novel pyrazole derivative | 持田制药株式会社 | 2017-07-18 | — | — | CN | disclosed |
| CN-105189493-B | Novel Pyrazole Derivatives | 持田制药株式会社 | 2017-04-12 | — | — | CN | disclosed |
| CN-106554351-A | The preparation method of pyrazole derivatives | 持田制药株式会社 | 2017-04-05 | — | — | CN | disclosed |
| CN-105189493-A | Novel Pyrazole Derivatives | MOCHIDA PHARM CO LTD | 2015-12-23 | — | — | CN | disclosed |
| CN-105188371-A | Erk inhibitors and uses thereof | CELGENE AVILOMICS RES INC | 2015-12-23 | — | — | CN | disclosed |
| CN-101646673-B | 3-amino-pyrrolo [3,4-C ] pyrazole-5 (1H,4H,6H) carbaldehyde derivatives as PKC inhibitors | PFIZER US | 2014-06-25 | — | — | CN | disclosed |
| EP-0445644-B1 | Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation | BASF AG (DE) | 1995-05-24 | — | — | EP | disclosed |
| US-5237063-A | TRIFLUORO- AND CHLORODIFLUOROMETHOXYPYRIMIDINES AND THE PREPARATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 1993-08-17 | — | — | US | disclosed |
| EP-0445644-A1 | Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation | BASF Aktiengesellschaft (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0375617-A1 | Process for the preparation of pyrimidine derivatives | CIBA-GEIGY AG (CH) | 1990-06-27 | — | — | EP | disclosed |