Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL2532781 | 1.00 | TSHR (0.55) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL893600 | 0.91 | ALDH1A1 (0.56) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL29387616 | 0.91 | ALDH1A1 (0.56) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL4725543 | 0.89 | ALDH1A1 (0.49) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| Ammonia Solution, Strong SCHEMBL8555602 | 0.88 | ALDH1A1 (0.48) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| Phosphoric Acid SCHEMBL6538345 | 0.88 | TSHR (0.55) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL1679319 | 0.87 | ALDH1A1 (0.47) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL18785100 | 0.87 | ALDH1A1 (0.47) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL15849845 | 0.87 | ALDH1A1 (0.47) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 | |
| SCHEMBL9305445 | 0.84 | ALDH1A1 (0.45) | TSHRNPSR1ALDH1A1MAPK1KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353822-A1 | Immunoenzymatic single-plate elisa method with competitive inhibitition for detecting antisporozoite antibodies of plasmodium falciparum | ENIRICERCHE S.p.A. (IT) | 1990-02-07 | — | — | EP | claimed |
| US-20050058636-A1 | Medicament against thrombotic diseases | ZLB BEHRING GMBH (DE) | 2005-03-17 | — | — | US | disclosed |
| EP-1344532-A1 | High molecular weight kininogen (HK) domain 5 derived peptides against thrombic diseases | Aventis Behring GmbH (DE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1344531-A1 | High molecular weight kininogen (HK) domain 5 derived peptides against thrombic diseases | Aventis Behring GmbH (DE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002076477-A1 | SKIN-TEST REAGENTS AND SERUM SPECIFIC IGE, IGG SUBTYPES DETECTION KITS, COMPRISING CRUDE EXTRACTS OF SPIDER MITES SUCH AS CITRUS RED MITE, TWO-SPOTTED SPIDER MITE AND EUROPEAN RED MITE | BIOALLETECH CO., LTD. (KR) | 2002-10-03 | — | — | WO | disclosed |
| US-5962404-A | CENTRAL NERVOUS SYSTEM DISORDERS | YEDA RESEARCH & DEVELOPMENT CO., LTD. (IL) | 1999-10-05 | — | — | US | disclosed |
| EP-0415321-B1 | Oligodendrocyte cytotoxic factor | YEDA RES & DEV (IL) | 1995-11-08 | — | — | EP | disclosed |
| US-5459079-A | Support for biologically active molecules which itself may be biologically active, process for its preparation and its biological applications | RHONE-POULENC CHIMIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0415321-A1 | Oligodendrocyte cytotoxic factor | YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED (IL) | 1991-03-06 | — | — | EP | disclosed |