Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.60 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455310 | 0.88 | MAPT (0.70) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL12760575 | 0.82 | MAPT (0.62) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL27543599 | 0.82 | KAT2B (0.59) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL16151564 | 0.81 | KAT2B (0.72) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL20968369 | 0.81 | HCAR3 (0.66) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL10428098 | 0.81 | HCAR3 (0.66) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL16152114 | 0.81 | HCAR3 (0.66) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL5747369 | 0.80 | PDK1 (0.49) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL29306545 | 0.80 | HCAR3 (0.67) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL5749088 | 0.80 | MAPT (0.45) | MAPTPOLBPKMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |