Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 7/20 | 0.43 |
| ▸ | HTR1B | P28222 | 6/20 | 0.43 |
| ▸ | HTR1D | P28221 | 5/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515521 | 0.96 | KDM4E (0.44) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6512563 | 0.96 | KDM4E (0.44) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6515965 | 0.95 | KDM4E (0.43) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6512538 | 0.93 | KDM4E (0.42) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6516837 | 0.93 | KDM4E (0.44) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6516094 | 0.91 | THRA (0.47) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6519190 | 0.90 | KDM4E (0.41) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6511519 | 0.90 | KDM4E (0.43) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6516591 | 0.90 | KDM4E (0.43) | KDM4ESLC6A4HTR1AHTR1BHTR1D | |
| SCHEMBL6523744 | 0.90 | KDM4E (0.41) | KDM4ESLC6A4HTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032874-A1 | Anticholesterol agents; arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 2005-02-10 | — | — | US | disclosed |
| US-6794406-B2 | FOR THERAPY AND PROPHYLAXIS OF ARTERIOSCLEROSIS AND HYPERCHOLESTEROLAEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 2004-09-21 | — | — | US | disclosed |
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-20030078288-A1 | Indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2003-04-24 | — | — | US | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078288-A1 | Indole derivatives | IDO1, IDO2, TPH2 | KDM4E 1199/4885SLC6A4 30/4885HTR1A 17/4885 |
| US-20050032874-A1 | Anticholesterol agents; arteriosclerosis | HMGCR, CYP46A1, EBP | KDM4E 2994/4885SLC6A4 928/4885HTR1A 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.