Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 2/20 | 0.36 |
| ▸ | ATP4B | P51164 | 2/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648222 | 0.95 | C5AR1 (0.43) | C5AR1BCHECRHR1MEP1BTSHR | |
| SCHEMBL648790 | 0.92 | C5AR1 (0.43) | C5AR1BCHEMEP1BTSHRHSD17B10 | |
| SCHEMBL1912882 | 0.91 | BCHE (0.39) | C5AR1BCHECRHR1MEP1BTSHR | |
| SCHEMBL648123 | 0.91 | C5AR1 (0.42) | C5AR1BCHECRHR1PPARGPPARA | |
| SCHEMBL650283 | 0.90 | C5AR1 (0.42) | C5AR1BCHECRHR1TSHRHSD17B10 | |
| SCHEMBL649156 | 0.90 | C5AR1 (0.42) | C5AR1MEP1BTSHRCALM1CAMKK2 | |
| SCHEMBL653237 | 0.90 | C5AR1 (0.40) | C5AR1MEP1BPPARGPPARAHTT | |
| SCHEMBL5135861 | 0.90 | CRHR1 (0.44) | C5AR1BCHECRHR1TSHRHSD17B10 | |
| SCHEMBL5135705 | 0.89 | CALM1 (0.45) | C5AR1BCHECRHR1TSHRATP4A | |
| SCHEMBL5138089 | 0.89 | TSHR (0.46) | C5AR1BCHECRHR1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |