SCHEMBL6516945

SCHEMBL6516945

FC(c1ccc(Br)cc1)C(F)(F)C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.36
HTR2A P28223 1/20 0.33
CTSK P43235 1/20 0.33
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA5A P35218 1/20 0.32
CA9 Q16790 1/20 0.32
CYP1A2 P05177 1/20 0.32
IGF1R P08069 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22159396 0.88 ESR1 (0.38) ESR1ESR2
SCHEMBL7956909 0.81 CYP2A6 (0.40) CYP2A6HTR2ACTSKESR1ESR2
SCHEMBL10578908 0.79 IDO1 (0.38) ESR1ESR2CA1CA2CA9
SCHEMBL3130888 0.77 TSHR (0.48) CYP2A6ESR1ESR2
SCHEMBL10821953 0.77 ESR1 (0.32) ESR1ESR2
SCHEMBL320072 0.77 ESR1 (0.54) ESR1ESR2CA1CA2CA5A
SCHEMBL28507546 0.77 CHRNA7 (0.38) ESR1ESR2CA1CA2CA5A
SCHEMBL8462292 0.77 ESR1 (0.54) ESR1ESR2CA1CA2CA5A
SCHEMBL323076 0.77 ALDH1A1 (0.37) ESR1ESR2
SCHEMBL7870015 0.76 POLB (0.39) HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117402106-A Multidentate organic ligand containing triphenylamine-terpyridine structure, metal supermolecular polymer, polymer film and preparation method 吉林大学 2024-01-16 CN disclosed
CN-111747900-B Novel electron transmission material 烟台盛华液晶材料有限公司 2023-06-27 CN disclosed
CN-110494531-B Luminescent material, compound, and organic light-emitting element 国立大学法人九州大学 2023-05-12 CN disclosed
CN-113651838-B Compound containing multiple boron-oxygen family atom hybrid fused ring units and preparation method and application thereof 中国科学院长春应用化学研究所 2023-03-24 CN disclosed
CN-113651838-A Compound containing multiple boron-oxygen family atom hybrid fused ring units and preparation method and application thereof 中国科学院长春应用化学研究所 2021-11-16 CN disclosed
CN-111747900-A Novel electronic transmission material 烟台盛华液晶材料有限公司 2020-10-09 CN disclosed
CN-110494531-A Luminescent material, compound and organic illuminating element UNIV KYUSHU 2019-11-22 CN disclosed
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed
US-6271248-B1 USED IN TREATING HYPERTENSION, PULMONARY HYPERTENSION, RENAL/ GLOMERULAR/MESANGIAL CELL DISORDERS, ENDOTOXEMIA, ISCHEMIA, TUMOR GROWTH, ATHERSCLEROSIS, RESTENOSIS, SUBARACHNOID HEMORRHAGE, PROSTATIC HYPERTROPHY, CONGESTIVE HEART FAILURE BRISTOL-MYERS SQUIBB COMPANY 2001-08-07 US disclosed
US-6080774-A Substituted biphenylsulfonamide endothelin antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2000-06-27 US disclosed
EP-0768305-A1 N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 1997-04-16 EP disclosed
US-4866156-A Poly(arylether) or poly(arylthioether) from 2,2-bis(fluorophenyl)-hexafluoropropane HUGHES AIRCRAFT COPMANY (US) 1989-09-12 US disclosed