Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 5/20 | 0.36 |
| ▸ | GABRD | O14764 | 5/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.36 |
| ▸ | GABRE | P78334 | 5/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24275849 | 0.79 | BAZ2B (0.36) | — | |
| SCHEMBL22424331 | 0.79 | TSHR (0.40) | KDM4EKMT2AGABRPGABRDGABRA1 | |
| SCHEMBL29953776 | 0.77 | HCAR2 (0.36) | KDM4EKMT2AGABRPGABRDGABRA1 | |
| SCHEMBL19897461 | 0.75 | KDM4E (0.35) | KDM4EHCAR2ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL22424328 | 0.74 | KDM4E (0.44) | KDM4EKMT2AGABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL7170504 | 0.73 | KDM4E (0.43) | KDM4EKMT2AGABRPGABRDGABRA1 | |
| SCHEMBL28724144 | 0.72 | SMN1; SMN2 (0.37) | HCAR2ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL22889774 | 0.71 | LRRK2 (0.38) | — | |
| SCHEMBL14354118 | 0.71 | KEAP1 (0.30) | — | |
| SCHEMBL9717808 | 0.70 | SLC1A3 (0.33) | KMT2ACYP1A2ALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| WO-2004099131-A2 | COMPOUNDS HAVING A FUSED, BICYCLIC MOIETY FOR BINDING TO THE MINOR GROOVE OF DSDNA | PHARMACIA CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
| US-6566336-B1 | For therapy and prophylaxis of various gene- inducible diseases | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2003-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009054-A1 | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA | PCNA, POLM, PBRM1 | KDM4E 3756/4885KMT2A 607/4885GABRP 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.