SCHEMBL6516972

SCHEMBL6516972

COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3ccc(OC)cc3O)n2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.66
KMT2A Q03164 8/20 0.54
MEN1 O00255 7/20 0.54
GFER P55789 1/20 0.54
MAPT P10636 4/20 0.54
TP53 P04637 2/20 0.54
MAPK1 P28482 2/20 0.54
TSHR P16473 1/20 0.54
HTT P42858 1/20 0.54
MAPK10 P53779 1/20 0.54
PTK2B Q14289 1/20 0.54
NCOA1 Q15788 1/20 0.54
NCOA3 Q9Y6Q9 1/20 0.54
IDH1 O75874 1/20 0.52
RAB9A P51151 3/20 0.50
CASP3 P42574 2/20 0.50
SENP8 Q96LD8 2/20 0.50
SENP7 Q9BQF6 2/20 0.50
SENP6 Q9GZR1 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13658285 1.00 NPC1 (0.66) NPC1KMT2AMEN1GFERMAPT
SCHEMBL17403068 0.95 NPC1 (0.60) NPC1KMT2AMEN1GFERMAPT
SCHEMBL13938601 0.94 NPC1 (0.68) NPC1KMT2AMEN1GFERMAPT
SCHEMBL195208 0.94 NPC1 (0.59) NPC1KMT2AMEN1GFERMAPT
SCHEMBL13299330 0.94 NPC1 (0.59) NPC1KMT2AMEN1GFERMAPT
SCHEMBL3013803 0.93 NPC1 (0.58) NPC1KMT2AMEN1GFERMAPT
SCHEMBL4411824 0.93 NPC1 (0.58) NPC1KMT2AMEN1GFERMAPT
SCHEMBL29649707 0.93 NPC1 (0.58) NPC1KMT2AMEN1GFERMAPT
SCHEMBL16788873 0.92 NPC1 (0.57) NPC1KMT2AMEN1GFERMAPT
SCHEMBL3683112 0.92 NPC1 (0.60) NPC1KMT2AMEN1GFERMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-11-21 US disclosed
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-10-03 US disclosed
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-10-03 US disclosed
EP-0654469-B1 Stabilised polymers containing o-hydroxyphenyl-s-triazines CIBA SC HOLDING AG (CH) 2001-08-22 EP disclosed
EP-0815071-B1 LIPOSOMOGENIC UV ABSORBERS CIBA SC HOLDING AG (CH) 2001-04-11 EP disclosed
US-6017556-A PROTECTING HUMAN HAIR FROM THE DAMAGING EFFECT OF ULTRAVIOLET RADIATION BY TREATING HUMAN HAIR WITH A LIPOSOMOGENIC ULTRAVIOLET RADIATION ABSORBER CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-25 US disclosed
US-6015575-A TRIAZINE, BENZOTRIAZOLE, BENZOPHENONE AND AMINOBENZOIC ACID DERIVATIVES AS RADIATION ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-18 US disclosed
US-5760111-A TEXTILE STABILIZERS WITH PHOTOSTABILIZERS, OXIDATION OR HEAT RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-06-02 US disclosed
EP-0834304-A2 Liposomogenic UV absorbers Ciba SC Holding AG (CH) 1998-04-08 EP disclosed
US-5688995-A SUNSCREEN AGENTS CIBA-GEIGY CORPORATION (US) 1997-11-18 US disclosed
US-5591850-A STABILIZERS FOR TEXTILE FIBERS, COSMETIC SUNSCREENS CIBA-GEIGY CORPORATION (US) 1997-01-07 US disclosed
EP-0743309-A1 o-Hydroxyphenyl-s-triazines as UV stabilisers CIBA-GEIGY AG (CH) 1996-11-20 EP disclosed
EP-0654469-A1 O-Hydroxyphenyl-s-triazines as stabilisers for polymers CIBA-GEIGY AG (CH) 1995-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF NPC1 1772/4885KMT2A 3472/4885MEN1 538/4885
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, MITF, PUF60 NPC1 3516/4885KMT2A 3216/4885MEN1 866/4885
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF NPC1 1772/4885KMT2A 3472/4885MEN1 538/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 NPC1 283/4885KMT2A 3290/4885MEN1 866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.