SCHEMBL6517070

SCHEMBL6517070

O=C(O)CC(NC(=O)C1CCNCC1)c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 17/20 0.46
ITGA2B P08514 17/20 0.46
ITGB1 P05556 2/20 0.46
ITGA4 P13612 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
F2R P25116 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6512380 0.93 ITGA4 (0.50) ITGB3ITGA2BITGB1ITGA4SMN1; SMN2
SCHEMBL6512464 0.91 SMN1; SMN2 (0.52) ITGB3ITGA2BITGB1ITGA4SMN1; SMN2
SCHEMBL6512385 0.89 SMN1; SMN2 (0.47) ITGB3ITGA2BITGB1ITGA4SMN1; SMN2
SCHEMBL6510704 0.84 SMN1; SMN2 (0.47) ITGB3ITGA2BITGB1ITGA4SMN1; SMN2
SCHEMBL6509549 0.83 ITGB1 (0.63) ITGB1ITGA4
SCHEMBL6529457 0.81 SMN1; SMN2 (0.59) ITGB3ITGA2BITGB1ITGA4SMN1; SMN2
SCHEMBL6513196 0.79 ITGB1 (0.53) ITGB1ITGA4
SCHEMBL6509525 0.78 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL6520158 0.77 ITGA4 (0.43) ITGB1ITGA4
SCHEMBL6512395 0.76 ITGB1 (0.49) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6953798-B1 β-alanine derivates CELLTECH R&D LIMITED (GB) 2005-10-11 US disclosed