SCHEMBL6517093

SCHEMBL6517093

COC(=O)CC(Nc1nc(NCCO)nc(OC)n1)c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1

nearest known ligand 0.70

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 16/20 0.70
ITGA4 P13612 16/20 0.70
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6513439 0.93 ITGB1 (0.72) ITGB1ITGA4ALDH1A1HPGDSMN1; SMN2
SCHEMBL5364460 0.82 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL6518082 0.78 ITGB1 (0.57) ITGB1ITGA4
SCHEMBL7449206 0.77 ITGB1 (0.91) ITGB1ITGA4
SCHEMBL6514203 0.75 ITGB1 (0.49) ITGB1ITGA4ALDH1A1SMN1; SMN2
SCHEMBL5368089 0.75 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5259497 0.73 ITGB1 (0.49) ITGB1ITGA4
SCHEMBL5367895 0.72 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL6109444 0.72 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5366263 0.72 ITGB1 (1.00) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6953798-B1 β-alanine derivates CELLTECH R&D LIMITED (GB) 2005-10-11 US disclosed