Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | FGF2 | P09038 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101452 | 0.87 | GCK (0.40) | GCKRAF1BRAFFGFR1FGF2 | |
| SCHEMBL6038760 | 0.86 | GCK (0.39) | GCKRAF1BRAFFGFR1FGF2 | |
| SCHEMBL6038763 | 0.85 | GCK (0.40) | GCKPPARGRAF1BRAFFGFR1 | |
| SCHEMBL5107640 | 0.80 | KDR (0.40) | PPARG | |
| SCHEMBL5113619 | 0.80 | GCK (0.40) | GCKRAF1BRAFFGFR1 | |
| SCHEMBL6038700 | 0.79 | MAP2K7 (0.40) | — | |
| SCHEMBL6514499 | 0.79 | SMN1; SMN2 (0.37) | PPARGFGFR1 | |
| SCHEMBL5101456 | 0.76 | FGFR1 (0.37) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL5101914 | 0.76 | GCK (0.39) | GCKRAF1BRAFFGFR1LIPE | |
| SCHEMBL5101352 | 0.75 | FGFR1 (0.42) | FGFR1FGF2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | GCK 3607/4885PPARG 869/4885RAF1 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.