Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15477734 | 0.86 | ALDH1A1 (0.49) | POLBALDH1A1HPGDGSK3AGSK3B | |
| SCHEMBL6517578 | 0.77 | HPGD (0.51) | ALDH1A1HPGDTSHRMAPTMEN1 | |
| SCHEMBL8654001 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HPGDGSK3AGSK3BTSHR | |
| SCHEMBL8651759 | 0.77 | HPGD (0.46) | POLBALDH1A1HPGDTSHRMAPT | |
| SCHEMBL12177225 | 0.76 | GSK3A (0.74) | POLBALDH1A1GSK3AGSK3BMAPT | |
| SCHEMBL9570665 | 0.76 | GSK3A (0.59) | POLBALDH1A1GSK3AGSK3BTSHR | |
| SCHEMBL9570668 | 0.76 | GSK3A (0.59) | POLBALDH1A1GSK3AGSK3BTSHR | |
| SCHEMBL7252535 | 0.76 | GSK3A (0.82) | POLBALDH1A1GSK3AGSK3BTSHR | |
| SCHEMBL8857111 | 0.75 | POLB (0.56) | POLBALDH1A1GSK3AGSK3BTSHR | |
| SCHEMBL8479288 | 0.75 | GSK3A (0.57) | POLBALDH1A1GSK3AGSK3BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261306-A1 | Anti-neurodegenerative agents | IKEDA, JOH-E (JP) | 2005-11-24 | — | — | US | disclosed |
| US-5929101-A | ADMINISTERING THIAZOLIDINEDIONE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5773426-A | IMPROVED GLUCOSE TRANSPORT | MASAKI SHIROTA (US) | 1998-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261306-A1 | Anti-neurodegenerative agents | SMN1; SMN2, PARK7, HTT | POLB 2431/4885ALDH1A1 4182/4885HPGD 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.