Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994786 | 0.93 | AGTR2 (0.42) | AGTR2AGTR1 | |
| SCHEMBL654994 | 0.93 | MME (0.41) | MMEAGTR2AGTR1 | |
| SCHEMBL667458 | 0.87 | AGTR2 (0.44) | AGTR2AGTR1 | |
| SCHEMBL667457 | 0.87 | AGTR2 (0.44) | AGTR2AGTR1 | |
| SCHEMBL653073 | 0.86 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL994431 | 0.86 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL650654 | 0.85 | AGTR2 (0.43) | AGTR2AGTR1 | |
| SCHEMBL652670 | 0.84 | AGTR2 (0.42) | AGTR2AGTR1 | |
| SCHEMBL656488 | 0.83 | AGTR2 (0.50) | AGTR2 | |
| SCHEMBL650895 | 0.83 | MME (0.42) | MMEAGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119634-B2 | Dual-acting pyrazole antihypertensive agents | THERAVANCE, INC. (US) | 2012-02-21 | — | — | US | disclosed |