Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FABP7 | O15540 | 3/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721693 | 0.92 | POLB (0.74) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL27495 | 0.83 | POLB (0.59) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL3777075 | 0.83 | POLB (0.59) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL572756 | 0.83 | POLB (0.59) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL3787744 | 0.83 | POLB (0.59) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL4665372 | 0.83 | POLB (0.59) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL19258989 | 0.81 | POLB (0.57) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL16199396 | 0.81 | POLB (0.57) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL15400698 | 0.81 | POLB (0.57) | POLBTDP1APEX1LMNAALDH1A1 | |
| SCHEMBL16199077 | 0.81 | POLB (0.57) | POLBTDP1APEX1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |