Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16141939 | 1.00 | MAPT (0.40) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL6519305 | 1.00 | MAPT (0.40) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL6566948 | 0.91 | MEN1 (0.38) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL15114583 | 0.88 | MAPT (0.40) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL1820679 | 0.87 | MAPT (0.39) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL7936504 | 0.86 | MAPT (0.39) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL17816955 | 0.86 | MAPT (0.39) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL16142024 | 0.86 | MAPT (0.39) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL17840419 | 0.86 | BTK (0.38) | KMT2AMEN1MAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL28302110 | 0.85 | KMT2A (0.39) | KMT2AMEN1MAPK1ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-B1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-2802326-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-04-18 | — | — | EP | disclosed |
| US-9770439-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9770439-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20160199355-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MAYERS SQUIBB COMPANY (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160199355-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MAYERS SQUIBB COMPANY (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160158200-A1 | Combinations of Hepatitis C Virus Inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2016-06-09 | — | — | US | disclosed |
| US-20160158200-A1 | Combinations of Hepatitis C Virus Inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2016-06-09 | — | — | US | disclosed |
| US-9326973-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-9326973-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20130281461-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-24 | — | — | US | disclosed |
| US-8497369-B2 | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| US-8497369-B2 | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| US-8497369-B2 | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| WO-2013106520-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-18 | — | — | WO | disclosed |
| US-20130183269-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130183269-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-18 | — | — | US | disclosed |
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | PKD1, BPHL, CYP11B2 | MAPT 565/4885KMT2A 4335/4885MEN1 899/4885 |
| US-20130281461-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | PKD1, BPHL, CYP11B2 | MAPT 565/4885KMT2A 4335/4885MEN1 899/4885 |
| US-20130183269-A1 | Hepatitis C Virus Inhibitors | HAVCR2, MAVS, EIF2AK2 | MAPT 3132/4885KMT2A 4038/4885MEN1 4834/4885 |
| US-20160199355-A1 | HEPATITIS C VIRUS INHIBITORS | HAVCR2, MAVS, EIF2AK2 | MAPT 3132/4885KMT2A 4038/4885MEN1 4834/4885 |
| US-20160158200-A1 | Combinations of Hepatitis C Virus Inhibitors | HAVCR2, EIF2AK2, MAVS | MAPT 3548/4885KMT2A 4192/4885MEN1 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.