Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653201 | 1.00 | GPR119 (0.37) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL651995 | 0.87 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL649591 | 0.87 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL653364 | 0.87 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3573962 | 0.85 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3576689 | 0.85 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL652300 | 0.81 | CHRNB2 (0.48) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL652015 | 0.81 | CHRNB2 (0.48) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14299579 | 0.79 | MAPT (0.47) | GPR119PIK3CA | |
| SCHEMBL653926 | 0.79 | GPR119 (0.49) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |